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KMID : 0370220150590010012
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Yakhak Hoeji
2015 Volume.59 No. 1 p.12 ~ p.16
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Synthesis of 8-Cycloalkoxychrysin Analogs and their Inhibitory Activity Against NO Production
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Kim Sung-Soo
Park Hae-Il
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Abstract
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Several 8-cycloalkoxychrysin analogs were synthesized from 6-benzyloxy-5,8-dihydroxyflavone and cycloalkanols in 2 steps and we evaluated their inhibitory activities against NO production from LPS-induced RAW 264.7 cells. Among tested analogs, two analogs with cyclopentyl substructure (796 and 798) showed strong inhibitory activity against NO production.
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KEYWORD
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chrysin, 8-cycloalkoxychrysin, anti-inflammatory, nitric oxide (NO)
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